All posts by markpaskewitz

Hard Times for French President Emmanuel Macron

 

New Kyowa Kirin Drug Effective against X-Linked Hypophosphatemia

Serving as National Institute of Clinical Research, Inc. vice president of clinical operations, Mark Paskewitz organizes a variety of clinical studies at affiliated sites in areas ranging from oncology to cardiology. Among Mark Paskewitz’ accomplishments has been his work in the development of a new Kyowa Hakko Kirin drug for X-Linked Hypophosphatemia (XLH), which received European Commission marketing authorization in early 2018.

A rare chronic and progressive musculoskeletal condition, XLH involves renal phosphate wasting and is related to too much of the hormone fibroblast growth factor 23 (FGF23) . Conventional treatments center on taking active vitamin D and phosphate on a daily basis. While this addresses FGF23 and its effects, it does not help resolve underlying issues that can cause children to develop a skeletal disease that results in decreased height and lower-extremity deformities.

The first FDA and EU-approved medication that addresses XLH’s underlying causes, Crysvita has been recognized for its outstanding contribution to public health by the European Medicines Agency. Crysvita works against FGF23 production as a fully human recombinant monoclonal IgG1 antibody, and has also been developed as a treatment for tumour-induced osteomalacia, which involves elevated FGF23 levels.

The Early Evolution of El Greco’s Style

 

Domenikos Theotokopoulos pic
Domenikos Theotokopoulos
Image: biography.com

The recipient of an MD from Drexel University and an MBA from the University of California, Irvine, Dr. Mark Paskewitz balances a busy career as a clinical operations executive with the pursuit of cultural interests. During his free time, Dr. Mark Paskewitz enjoys listening to classical music, visiting museums, and reading about art. He counts El Greco among his favorite artists.

Born as Domenikos Theotokopoulos in 1541 on the island of Crete, El Greco studied to be an icon painter as a youth. Immersed in Byzantine art as a student, he began working as an icon painter and then moved to Venice to join Titian’s studio, where he absorbed the new ideas of Renaissance artists.

However, it wasn’t until El Greco moved to Rome in 1570 that he began developing the style he is known for today. The shift occurred when he encountered the work of the Mannerists, a school of artists who believed that a work of art drew more value from its meaning and philosophy than from its imitation of nature.

El Greco melded his Byzantine and Renaissance training with these Mannerist ideas to develop a revolutionary style that included elongated figures, dramatic highlights, and unusual color choices. His style has proved influential over the centuries, prefiguring major movements such as Expressionism and Cubism.